Why the study?
Does Angiotensin II overexpression increase cardiac ET-1 production in vivo in transgenic hypertensive mice?
Population
20-week-old male transgenic hypertensive mice (THM) overexpressing human renin and angiotensinogen genes
Comparison
Transgenic overexpression of Angiotensin II… vs Control mice
Design
Preclinical
Authors
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Local ET-1 upregulation by Ang II may contribute to hypertrophy in this model; hypothesis-generating and should not yet change practice.
Does Angiotensin II overexpression increase cardiac ET-1 production in vivo in transgenic hypertensive mice?
In vivo overexpression of Angiotensin II increases local cardiac ET-1 production, which may contribute to cardiac hypertrophy without affecting short-term blood pressure.
MAKI et al. (1998) studied this question.
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