May 1, 1994Circulation

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

View Full Paper

Ask AI

Bookmark

Why the study?

Does the endothelin ETA receptor antagonist BQ123 prevent cardiac hypertrophy in adult rats with hemodynamic overload?

Structured PICO

Does the endothelin ETA receptor antagonist BQ123 prevent cardiac hypertrophy in adult rats with hemodynamic overload?

Population

40 adult rats subjected to left ventricular overload with aortic banding or sham operation

Intervention

BQ123 (endothelin ETA receptor antagonist) 250 micrograms/h administered continuously by an osmotic pump starting 24 hours before operation

Comparator

No BQ123 administration (sham-operated or aortic banding alone)

Outcome

Cardiac hypertrophy assessed by the ratio of left ventricular weight to body weight, diameter of cardiomyocytes, and transcriptional markers (skeletal alpha-actin and atrial natriuretic peptide mRNA)surrogate

Endogenous ET-1 plays a role in the early phase of pressure overload-induced cardiac hypertrophy in vivo, which can be transiently blocked by an ETA receptor antagonist.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

ETA blockade may transiently blunt early hypertrophy in rat overload models; leaves open durability of ETA antagonism on remodeling.

Cite This Study

Hiroe et al. (1994) studied this question.

synapsesocial.com/papers/6a821c4f1fb4be735b3f0cd5 https://doi.org/10.1161/01.cir.89.5.2198

View Full Paper

Ask AI

Bookmark

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

Structured PICO

Discussion

Implication

Cite This Study

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider