L-Arginine treatment decreased infarct size by 31% (101 vs 147 mm3, P<0.05) in spontaneously hypertensive rats subjected to distal middle cerebral arterial and ipsilateral common carotid occlusion.
Does L-arginine reduce infarct size in spontaneously hypertensive rats subjected to focal cerebral ischemia?
L-arginine administration significantly reduces infarct size in a rat model of focal cerebral ischemia, suggesting a potential neuroprotective role via nitric oxide synthesis.
Effect estimate: decreased by 31%
Absolute Event Rate: 101% vs 147%
p-value: p=< 0.05
L-Arginine, but not D-arginine, serves as a precursor for the synthesis of nitric oxide (NO), a potent dilator of cerebral blood vessels. We examined the effects of administering L-arginine (300 mg/kg ip) on the volume of infarction in two models of focal cerebral ischemia in spontaneously hypertensive rats (SHR). L-Arginine was administered before (16 and 3 h) and after (5 min and 2 h) vessel occlusion, and animals were killed 24 h later. L-Arginine treatment decreased infarct size in rats subjected to distal middle cerebral arterial (MCA) plus ipsilateral common carotid arterial (CCA) occlusion by 31% 147 +/- 12 (saline) vs. 101 +/- 9 mm3 (L-arginine), P < 0.05. D-Arginine, administered according to the same dosage and protocol, was without effect. In the group subjected to proximal MCA occlusion, L-arginine decreased infarction size in the striatum by 28% 47 +/- 5 (saline) vs. 34 +/- 3 mm3 (L-arginine), P < 0.05 and neocortex by 11% 193 +/- 7 (saline) vs. 171 +/- 8 mm3 (L-arginine), P < 0.05. Changes in blood pressure or other measured physiological parameters did not account for the observed differences. The possible use of L-arginine for the treatment of focal cerebral ischemia merits further investigation.
Morikawa et al. (Sun,) conducted a other in Focal cerebral ischemia. L-arginine vs. Saline was evaluated on Volume of infarction (infarct size) (decreased by 31%, p=< 0.05). L-Arginine treatment decreased infarct size by 31% (101 vs 147 mm3, P<0.05) in spontaneously hypertensive rats subjected to distal middle cerebral arterial and ipsilateral common carotid occlusion.
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