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October 1, 1970Circulation ResearchOpen Access

Strength-Duration Curves for Ventricular Defibrillation in Dogs

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Why the study?

What are the optimal strength-duration parameters for ventricular defibrillation in dogs using capacitor-discharge and half-sinusoidal pulses?

Population

Dogs (preclinical model for ventricular defibrillation)

Design

Preclinical

Authors

LGL. A. GeddesWTWillis A. TackerJMJ McFarlane

Discussion

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Overview

Hypothesis-generating for energy-efficient defibrillation waveforms in animals; leaves open translation to human clinical practice.

Structured PICO

What are the optimal strength-duration parameters for ventricular defibrillation in dogs using capacitor-discharge and half-sinusoidal pulses?

P
Population
Dogs (preclinical model for ventricular defibrillation)
I
Intervention
Capacitor-discharge and half-sinusoidal pulses of current of various durations
O
Outcome
Threshold voltage and current necessary for ventricular defibrillation (expressed as energy, peak current, and charge per gram of heart)surrogate

Half-sinusoidal current waveforms require less energy for ventricular defibrillation in dogs, with an optimal duration of 1.25 to 8.3 msec for minimum energy.

Cite This Study

Geddes et al. (1970) studied this question.

synapsesocial.com/papers/6a2178f6af2526c2895fa1a7https://doi.org/10.1161/01.res.27.4.551
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