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May 7, 1993Science

Ryanodine Receptor Adaptation: Control Mechanism of Ca 2+ -Induced Ca 2+ Release in Heart

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Population

Single cardiac ryanodine receptor (RyR) channels

Design

Preclinical

Key result

Single cardiac ryanodine receptor channels adapted to maintained Ca2+ stimuli, preserving their ability to respond to a second larger Ca2+ stimulus.

Authors

SGSándor GyörkeMFMichael Fill

Discussion

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Overview

RyR adaptation may enable graded CICR in cardiomyocytes; leaves open its role in human HF or arrhythmias.

Structured PICO

P
Population
Single cardiac ryanodine receptor (RyR) channels
I
Intervention
Application of caged calcium ion (Ca2+) methodology with maintained Ca2+ stimuli
O
Outcome
Adaptation of RyR channels to maintained Ca2+ stimuli and preservation of response to a second Ca2+ stimulus

RyR adaptation may represent a fundamental molecular control mechanism for smoothly graded Ca2+-induced Ca2+ release in the heart.

Cite This Study

Györke et al. (1993) studied this question. Maintained Ca2+ stimuli was evaluated on Adaptation of single cardiac ryanodine receptor (RyR) channels. Single cardiac ryanodine receptor channels adapted to maintained Ca2+ stimuli, preserving their ability to respond to a second larger Ca2+ stimulus.

synapsesocial.com/papers/6a21b28f4f27a676ef8ba934https://doi.org/10.1126/science.8387229
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