Single cardiac ryanodine receptor channels adapted to maintained Ca2+ stimuli, preserving their ability to respond to a second larger Ca2+ stimulus.
RyR adaptation may represent a fundamental molecular control mechanism for smoothly graded Ca2+-induced Ca2+ release in the heart.
Adaptation of single cardiac ryanodine receptor (RyR) channels was demonstrated by application of the caged calcium ion (Ca2+) methodology. In contrast to conventional desensitization found in surface membrane ligand-gated channels, single cardiac RyR channels adapted to maintained Ca2+ stimuli, preserving their ability to respond to a second (larger) Ca2+ stimulus. RyR adaptation may represent a molecular control mechanism for smoothly graded Ca(2+)-induced Ca2+ release in heart and may be a fundamental feature of channels, including the inositol triphosphate receptor, that are involved in intracellular Ca2+ signaling in many cell types.
Györke et al. (Fri,) reported a other. Maintained Ca2+ stimuli was evaluated on Adaptation of single cardiac ryanodine receptor (RyR) channels. Single cardiac ryanodine receptor channels adapted to maintained Ca2+ stimuli, preserving their ability to respond to a second larger Ca2+ stimulus.