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April 13, 2018Bioscience Reports17 citationsOpen Access

Meta-analysis of trimetazidine treatment for cardiomyopathy

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Why the study?

Does trimetazidine improve echocardiographic and exercise parameters in patients with cardiomyopathy?

Population

898 patients with cardiomyopathy

Comparison

Trimetazidine (TMZ) vs Control group

Design

Meta-analysis

Key result

Trimetazidine treatment significantly increased left ventricular ejection fraction in patients with cardiomyopathy (95% CI 5.46-7.84; P<0.001).

Authors

QFQian FanZNZhaozhuo NiuLMLiqing Ma

Discussion

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Overview

Supports adjunctive trimetazidine in cardiomyopathy; confirms LVEF benefits across pooled trials.

Study Design

Type

Meta-Analysis (n=898)

Structured PICO

Does trimetazidine improve echocardiographic and exercise parameters in patients with cardiomyopathy?

P
Population
898 patients with cardiomyopathy included in a meta-analysis comparing trimetazidine treatment to control.
I
Intervention
Trimetazidine (TMZ)
C
Comparator
Control group
O
Outcome
Cardiopulmonary exercise testing (resting heart rate, peak heart rate, peak systolic blood pressure, and resting systolic blood pressure) and echocardiographic results (LVEF, LVESV, LVEDV, SWTSI, LVESD, and LVEDD)surrogate

Trimetazidine treatment significantly improves left ventricular ejection fraction and reduces left ventricular volumes and dimensions in patients with cardiomyopathy.

Main Result

p-value: p=<0.001

Limitations

  • Publication bias was present for left ventricular end-diastolic volume (LVEDV)

Cite This Study

Fan et al. (2018) conducted a meta-analysis in cardiomyopathy (n=898). Trimetazidine vs. Control was evaluated on Left ventricular ejection fraction (LVEF) (95% CI 5.46-7.84, p=<0.001). Trimetazidine treatment significantly increased left ventricular ejection fraction in patients with cardiomyopathy (95% CI 5.46-7.84; P<0.001).

synapsesocial.com/papers/6a226db66f3039e14eff610ehttps://doi.org/10.1042/bsr20171583
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