Distinct signaling mechanisms drive the divergent outcomes of adaptive physiological left ventricular hypertrophy in athletes versus pathological hypertrophy in heart failure.
This review outlines the signaling mechanisms that differentiate adaptive physiological hypertrophy in athletes from pathological remodeling in heart failure.
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Cardiac remodeling is typically associated with disease and can lead to heart failure. In contrast, remodeling that occurs in the athlete's heart is considered an adaptive physiological response. This review provides an overview of signaling mechanisms responsible for inducing left ventricular hypertrophy in the athlete's heart and in settings of pathological hypertrophy and heart failure.
Weeks et al. (Fri,) reported a other. Distinct signaling mechanisms drive the divergent outcomes of adaptive physiological left ventricular hypertrophy in athletes versus pathological hypertrophy in heart failure.