Key result
Distinct signaling mechanisms drive the divergent outcomes of adaptive physiological left ventricular hypertrophy in athletes versus pathological hypertrophy in heart failure.
Population
Athlete's heart and failing heart (pathological hypertrophy and heart failure)
Design
Review
Authors
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Does not guide clinical differentiation of hypertrophy phenotypes; leaves open targeted pathway modulation for future translational research.
This review outlines the signaling mechanisms that differentiate adaptive physiological hypertrophy in athletes from pathological remodeling in heart failure.
Weeks et al. (2011) studied this question. Distinct signaling mechanisms drive the divergent outcomes of adaptive physiological left ventricular hypertrophy in athletes versus pathological hypertrophy in heart failure.
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