Decreasing stimulation frequency during period pacing in a computational model consistently caused chaos at the transition to early afterdepolarizations via Hopf and homoclinic bifurcations.
This computational model provides a dynamical explanation for the irregular early afterdepolarization behavior frequently observed in cardiac experiments.
Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.
Tran et al. (Thu,) conducted a other in Cardiac early afterdepolarizations. Decreased stimulation frequency during period pacing was evaluated on Occurrence of chaos and early afterdepolarizations (EADs). Decreasing stimulation frequency during period pacing in a computational model consistently caused chaos at the transition to early afterdepolarizations via Hopf and homoclinic bifurcations.