Key result
Decreasing stimulation frequency during period pacing in a computational model consistently caused chaos at the transition to early afterdepolarizations via Hopf and homoclinic bifurcations.
Population
Model of cardiac cells exhibiting early afterdepolarizations (EADs)
Design
Preclinical
Authors
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Supports bifurcation-based EAD modeling; leaves open clinical translation to arrhythmia management.
This computational model provides a dynamical explanation for the irregular early afterdepolarization behavior frequently observed in cardiac experiments.
Tran et al. (2009) studied Cardiac early afterdepolarizations. Decreased stimulation frequency during period pacing was evaluated on Occurrence of chaos and early afterdepolarizations (EADs). Decreasing stimulation frequency during period pacing in a computational model consistently caused chaos at the transition to early afterdepolarizations via Hopf and homoclinic bifurcations.
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