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June 10, 2021PLoS ONEOpen Access

Medication-related hospital readmissions within 30 days of discharge—A retrospective study of risk factors in older adults

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Why the study?

Previous studies showed that approximately 20% of hospital readmissions are medication-related and 70% of these are possibly preventable, prompting investigation into risk factors for such readmissions within 30 days of discharge in older adults.

What are the risk factors for medication-related hospital readmissions within 30 days of discharge in older adults?

Population

360 older adults (≥65 years) readmitted within 30 days and 360 comparison patients

Comparison

Possibly or unlikely medication-related 30-day readmissions vs a comparison group

Design

Retrospective medical records study

Follow-up

30 days

Key result

Excessive polypharmacy (OR 1.74; 95% CI 1.07-2.81), medication dosage adjustments, and living alone significantly increased the odds of possibly medication-related 30-day hospital readmissions.

Authors

MGMaria GlansAEAnnika Kragh EkstamUJUlf Jakobsson

Discussion

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Member takes

Overview

Excessive polypharmacy may raise medication-related readmission risk; leaves open whether deprescribing interventions improve outcomes in prospective studies.

Study Design

Type

Observational (n=720)

Structured PICO

What are the risk factors for medication-related hospital readmissions within 30 days of discharge in older adults?

P
Population
720 older adults (≥65 years) evaluated in a retrospective study to identify risk factors for medication-related hospital readmissions within 30 days of discharge.
E
Exposure
Risk factors including living arrangements, polypharmacy, potentially inappropriate medication therapy, and changes made to medication regimens at initial discharge
C
Comparator
Comparison group (n=360)
O
Outcome
Risk factors associated with possibly medication-related readmissions to hospital within 30 days of discharge

Main Result

Odds Ratio: 1.74 (95% CI 1.07–2.81)

In older adults, excessive polypharmacy, comorbidity burden, medication dosage adjustments at discharge, and living alone significantly increase the risk of medication-related 30-day hospital readmissions.

Cite This Study

Glans et al. (2021) conducted an observational in Hospital readmission (n=720). Excessive polypharmacy, medication dosage adjustments, and living alone vs. Absence of these risk factors was evaluated on Possibly medication-related readmissions within 30 days of discharge (OR 1.74, 95% CI 1.07-2.81). Excessive polypharmacy (OR 1.74; 95% CI 1.07-2.81), medication dosage adjustments, and living alone significantly increased the odds of possibly medication-related 30-day hospital readmissions.

synapsesocial.com/papers/6a41bba0c37244ac43773a8ehttps://doi.org/10.1371/journal.pone.0253024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preventable medication-related readmissions involving older adults: a retrospective cohort analysis2025
  2. 2Risk of 30-day hospital readmission associated with medical conditions and drug regimens of polymedicated, older inpatients discharged home: a registry-based cohort study2021 · 38 citations
  3. 3Medication-Related Hospital Readmissions Within 30 Days of Discharge: Prevalence, Preventability, Type of Medication Errors and Risk Factors2021 · 83 citations
  4. 4Hospital readmission within 30 days of older adults hospitalized in a public hospital2022
  5. 5Causes and correlates of 30 day and 180 day readmission following discharge from a Medicine for the Elderly Rehabilitation unit2018 · 37 citations