What question did this study set out to answer?

To investigate the maturation process of the human endocrine pancreas during early postnatal periods.

July 1, 2026Open Access

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods

Key Points

To investigate the maturation process of the human endocrine pancreas during early postnatal periods.
Analyzed 123 pediatric pancreata through systematic histological examination.
Assessed islet formation, cell rearrangement, vascularization, and glucagon secretion dynamics.
Detailed dynamic islet formation observed in the first decade of life.
Noted asynchronous patterns in vascularization and innervation.
Progressive glucagon secretion maturation was documented over early childhood.

Abstract

Systematic analysis of 123 pediatric pancreata reveals dynamic postnatal islet formation, endocrine cell rearrangement, asynchronous vascularization/innervation, and progressive glucagon secretory maturation during the first decade of life.

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