Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods

Diane C. Saunders; Fan Feng; Alexander L. Hopkirk; Kristie Aamodt; Nathaniel Hart; Fong Cheng Pan; Conrad V. Reihsmann; Nike Izmaylov; Shaojun Mei; Brandon A. Sherrod; Corey Davis; NONGYAO NONPANYA; Yasminye D. Pettway; Keval P. Patel; KAI S. LEE; Jeff Duryea; Rachana Haliyur; Radhika Aramandla; Heather Durai; Greg Poffenberger; Alexandra Martin; Amanda L. Posgai; Irina Kusmartseva; Maria Beery; Mingder Yang; Ke Xu; Hakmook Kang; Dale L. Greiner; Leonard D. Shultz; Jeeyeon Cha; Rita Bottino; Mark A. Atkinson; Christopher V.E. Wright; Alvin C. Powers; Marcela Briššová

doi:10.1038/s41467-026-73854-y

Key Points

To investigate the maturation process of the human endocrine pancreas during early postnatal periods.
Analyzed 123 pediatric pancreata through systematic histological examination.
Assessed islet formation, cell rearrangement, vascularization, and glucagon secretion dynamics.
Detailed dynamic islet formation observed in the first decade of life.
Noted asynchronous patterns in vascularization and innervation.
Progressive glucagon secretion maturation was documented over early childhood.

Implication

Systematic analysis maps endocrine cell development and secretory maturation in young children, indicating key growth patterns.

Abstract

Systematic analysis of 123 pediatric pancreata reveals dynamic postnatal islet formation, endocrine cell rearrangement, asynchronous vascularization/innervation, and progressive glucagon secretory maturation during the first decade of life.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Saunders et al. (2026) studied this question.

synapsesocial.com/papers/6a44ae015cd2549c8bc436f8 https://doi.org/10.1038/s41467-026-73854-y

View Full Paper

Ask AI

Bookmark

Share

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods

Key Points

Implication

Abstract

Discussion

Cite This Study

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading