Ludwig Cancer Research

Recent papers from Ludwig Cancer Research

1. LUBAC PUB domain interactions restrict Met1-linked ubiquitination to prevent murine embryonic lethality and immune pathologyNature Communications · 2026
2. Chemotherapy enhances cancer vaccine efficacy and expands stem-like TCF1+CD8+ T cellsCancer Cell · 2026
3. BRN2 suppresses stress-induced hair greying2026
4. Tumor DNA methylation subtypes and expression levels of CFISH predict response and overall survival to immunochemotherapyMed · 2026
5. Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signalingLeukemia · 2026
6. Systemic hypoxia or Foxp3-directed Phd2 silencing cause immune activation and augment the protective immune response to BCGCommunications Biology · 2026
7. Ciliary regulation of melanogenesis unveils moonlighting roles for Joubert Syndrome proteins2026
8. Clinical evaluation of AI-assisted quantitative marrow fibrosis assessment using Continuous Indexing of Fibrosis (CIF)Leukemia · 2026
9. Inflammatory macrophages promote metastatic potential in Triple-negative Breast Cancer through Integrated Stress Response signalingJournal of Experimental & Clinical Cancer Research · 2026
10. A transient MXD4-dependent proliferative pause enables survival of brain micrometastasesCancer Cell · 2026
11. Dual-oxygen pancreatic cancer organoids recapitulate basal–classical heterogeneity validated by spatial transcriptomicsBritish Journal of Cancer · 2026
12. Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT)Nature Communications · 2026
13. Development of a universal imaging “phenome” using shape, appearance and motion (SAM) features and the SAM Phenotype Observation Tool (SPOT)Nature Communications · 2026
14. Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn’s diseaseNature Immunology · 2026
15. CD155 regulates tumor growth and susceptibility to T cell-mediated killing in diffuse midline gliomaNeuro-Oncology · 2026
16. Development and Reliability of a Competency Assessment Tool for Magnetic Sphincter Augmentation of the Esophagus (MSA CAT) as Part of a Video-based Surgical Quality Assurance Program for the GOLF TrialAnnals of Surgery · 2026
17. Spatial remodeling of the thymic stroma with age disrupts niches for T cell selection and tolerance2026
18. Metabolic buffering restricts phenotype switching in melanomaThe EMBO Journal · 2026
19. CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosisScience Translational Medicine · 2026
20. Advancing cancer detection and treatment using longitudinal routine clinical dataCell · 2026