MRC Protein Phosphorylation and Ubiquitylation Unit

Recent papers from MRC Protein Phosphorylation and Ubiquitylation Unit

1. Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation StrategiesChemMedChem · 2026
2. Ubiquitylation of unbranched glycogen and glycogenin-1 in branching enzyme-deficient cellsBiochemical and Biophysical Research Communications · 2026
3. IRAK4 autophosphorylation functions as a molecular switch to regulate death domain assembly and Myddosome maturationNature Communications · 2026
4. The 20 th EFMC Short Course on Medicinal Chemistry Dedicated to Atypical Approaches Focusing on Protein TargetsChemMedChem · 2026
5. NEK1 autophosphorylation is disrupted by amyotrophic lateral sclerosis-associated missense variants: activity biomarkers and structural insightsOpen Biology · 2026
6. Genetic and pharmacologic inhibition of Keap1 dampens the pro-fibrotic program in human hepatic stellate cellsScientific Reports · 2026
7. Functional pathway phenotyping reveals increased LRRK2 activity beyond recognised genetic causes of Parkinson’s diseasenpj Parkinson s Disease · 2026
8. A New Gain-of-Function NLRP1 Variant Is Associated with Inflammasome Activation and Disease Severity in SLC25A38 Congenital Sideroblastic Anemia Case ReportJournal of Personalized Medicine · 2026
9. Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradationScientific Reports · 2026
10. Generalised tetanus: the San Lazaro Hospital experiencePractical Neurology · 2026
11. The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitmentBritish Journal of Pharmacology · 2026
12. Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics DevelopmentAdvanced Healthcare Materials · 2026
13. Targeted degradation of alpha-synuclein impedes PFF-induced aggregationnpj Parkinson s Disease · 2026
14. USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavageNature Communications · 2026
15. FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activatorsThe EMBO Journal · 2026
16. Protocol for PI3K inhibitor-free differentiation and maturation of human iPSC-derived arterial- and venous-like endothelial cellsSTAR Protocols · 2026
17. Rapid glycolytic metabolism underpins mucosal-associated invariant T cell functional responses to innate cytokinesThe Journal of Immunology · 2026
18. ChemBioParis 2025: Approaching Biology Through Chemistry in the City of LightChemBioChem · 2026
19. Expression of RUNX1::RUNX1T1 deregulates the proteome, induces C/EBPβ suppression, and blocks myeloid differentiationBlood Neoplasia · 2026
20. Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteinsCell Reports · 2026