New York Structural Biology Center

Recent papers from New York Structural Biology Center

1. Utilization of the Nortropinone Scaffold in the Structure-Guided Design of Potent Inhibitors of Human Cathepsin L and the Chymotrypsin-like Proteases of SARS-CoV-2 and MERS-CoVACS Pharmacology & Translational Science · 2026
2. Near UV Photo-Degradation of IgG1-Fc Promoted by His and Fe(III): Probing the Role of the Metal-Binding Pocket by Site-Directed MutagenesisMolecular Pharmaceutics · 2026
3. Enterovirus RNase L inhibiting RNAs are highly conserved with limited phylogenetic distributionRNA · 2026
4. A molecular safeguard in Escherichia coli Braun’s lipoprotein (Lpp) biogenesismBio · 2026
5. Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantroleneNature Communications · 2026
6. Cryoprotectants-assisted plunge freezing of thick brain tissue specimens for targeted physiologically relevant cryo-imaging in situCell Reports Methods · 2026
7. A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistancemBio · 2026
8. Photocycle Structures of a Myxobacterial Phytochrome as Revealed by Cryo-EMMicroscopy and Microanalysis · 2026
9. Exploring Compressive Sensing in 4D-STEM Cryo-ET and FIB for Structural BiologyMicroscopy and Microanalysis · 2026
10. Beyond Icosahedrons: Exploring the Structural Space of Polymorphic HK97 Family Protein CagesMicroscopy and Microanalysis · 2026
11. Enabling CryoEM Adoption and Training Through Immersive Visualization TechnologiesMicroscopy and Microanalysis · 2026
12. NSP15 in SARS-CoV-2: ADPRP macrodomain regulation and small-molecule inhibitionJournal of Biomolecular Structure and Dynamics · 2026
13. Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activityeLife · 2026
14. A bacteriophytochrome Pr/Pfr heterodimer studied through single-particle time-resolved cryo-electron microscopyCommunications Chemistry · 2026
15. SCM-1/SCAMP Maintains Microdomain Boundaries and Cargo Sorting within the Endosomal System2026
16. Molecular insight into microtubule nucleation by the XMAP215/γ-TuRC moduleNature Communications · 2026
17. Structure-guided design of calcium-dependent protein kinase 1 (CDPK1) inhibitors for cryptosporidiosis.2026
18. Streamlined correlative live-confocal and SBF-SEM imaging reveals early inflammatory dendritic changes induced by microglia.2026
19. Myosin forces remodel F-actin for mechanosensitive protein recognitionNature · 2026
20. Examining Genetic Variants Associated with FOXP1 Syndrome through Molecular Dynamics of Its DNA-Binding Domain and Self-Organizing MapsJournal of Chemical Information and Modeling · 2026