Koch Institute for Integrative Cancer Research At MIT

Recent papers from Koch Institute for Integrative Cancer Research At MIT

1. A high-throughput all-optical platform for mapping gene perturbations to electrophysiology2026
2. Dendritic cell-targeting virus-like particles as mRNA carriers induce Th1-skewed humoral and cellular immunityFrontiers in Immunology · 2026
3. A designer protein binder of KRAS enables exogenous protein degradationProtein Science · 2026
4. Fusion-independent virus-like particles enable rapid detection of antibody-mediated inhibition of ligand-receptor interactionsFrontiers in Immunology · 2026
5. Bioinspired soft enteroscopic robot for intestinal locomotion, steering, and interventionScience Robotics · 2026
6. Decoding & manipulating human intercellular signaling via scalable cell-free protein synthesis2026
7. Multiple bottlenecks constrain presentation of Mycobacterium tuberculosis antigens on MHC class I2026
8. Dissection of Polycomb complexes reveals canonical PRC1-independent 3D chromatin interactions2026
9. Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowdingNature Cell Biology · 2026
10. A versatile titanium–hydrogel platform bridging hard and soft tissue for joint arthroplastyCommunications Materials · 2026
11. Multiomic analysis of malignant ascites defines RORC -expressing dendritic cells at sites of metastasisScience Immunology · 2026
12. Accelerated discovery of thermostable mRNA–lipid nanoparticle vaccines using data-efficient AINature Biotechnology · 2026
13. A genome-scale ORF screen for resilience factors that protect the RPE and restore vision in aged mice2026
14. Failure to release from the ER translocon induces 60S ribosome degradation2026
15. Structural insights into DHODH-mediated catalysis and drug resistance2026
16. Fatty acid synthesis restricts HIV-1 infection through regulation of the nuclear envelope in CD4+ T cells2026
17. Folate deficiency disrupts key metabolic transitions within the developing neural ectoderm2026
18. Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunityImmunity · 2026
19. The diverse functions of viral microproteins2026
20. Voltage imaging of neurons distributed across entire brains of larval zebrafishNature Methods · 2026