Integrated BioTherapeutics (United States)

Recent papers from Integrated BioTherapeutics (United States)

1. Core Coefficient quantifies transcription-factor functional dominance for therapeutic target selection2026
2. The transformative potential of lipid nanoparticles tailored for acute myeloid leukemia immunotherapyFrontiers in Immunology · 2026
3. PLP1-triggered NOT gate to address neurotoxicity risk of PSMA-targeted prostate cancer therapyJournal for ImmunoTherapy of Cancer · 2026
4. PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor EfficacyAdvanced Science · 2026
5. An inducible signal 1 booster overcomes limited access to antigen for solid tumor cell therapyMolecular Therapy Oncology · 2026
6. The paraspeckle protein NONO potentiates the antiviral innate immune response through chromatin regulation2026
7. Ebola at 50 — Lessons for Outbreak Response and PreparednessNew England Journal of Medicine · 2026
8. Staphylococcus aureus superantigens drive a concentration-dependent neutrophilic or eosinophilic pulmonary inflammation in mouse models of cystic fibrosisThe Journal of Immunology · 2026
9. A logic-gated chimeric antigen receptor T-cell (CAR T) therapy with an armored, membrane-tethered IL-12 booster in patients with advanced solid tumors with HLA-A*02 loss of heterozygosity (LOH): EVEREST-2, a phase 1/2 study.Journal of Clinical Oncology · 2026
10. Initial safety and efficacy of A2B694, a logic-gated mesothelin (MSLN)–targeted Tmod chimeric antigen receptor T-cell (CAR T) therapy in patients with advanced solid tumors with HLA-A*02 loss of heterozygosity (LOH).Journal of Clinical Oncology · 2026
11. A phase 1b/2 study of JK06, a 5T4-targeted antibody-drug conjugate (ADC), in patients with unresectable locally advanced or metastatic cancer.Journal of Clinical Oncology · 2026
12. Influence of onboard, tethered IL-12 on potency of the Tmod NOT gate and selectivity.Journal of Clinical Oncology · 2026
13. The novel ErbB4 agonist JK07 modulates gene expression in key cardiac cells. insights from single-nuclei transcriptomics in a murine heart failure modelCardiovascular Research · 2026
14. The path to clinical application of human microglia transplantation for the treatment of CSF1R-Related disorderExpert Review of Neurotherapeutics · 2026
15. ERBB4 Activation as a New Therapy for Atrial Remodeling and FibrillationHeart Rhythm · 2026
16. A Tri-specific EGFR/cMet/VEGF Antibody Demonstrates Potent Multi-Mechanistic Activity in Preclinical Triple-Negative Breast Cancer Models.2026
17. Abstract CT250: A phase 1b / 2 study of JK06, a 5T4-targeted antibody drug conjugate, in patients with unresectable locally advanced or metastatic cancerCancer Research · 2026
18. Abstract CT179: SON-1010 (IL12-FHAB) synergizes with trabectedin in advanced soft-tissue sarcomaCancer Research · 2026
19. Abstract CT094: A Phase 1/2 study of BDC-4182, a claudin18.2-targeting next generation immune-stimulating antibody conjugate (ISAC), in patients with advanced gastric and gastroesophageal cancerCancer Research · 2026
20. Comparative analysis of NSG and NBSGW mice for preclinical evaluation of gene-modified human hematopoietic stem and progenitor cellsStem Cell Research & Therapy · 2026