Altos Labs

Recent papers from Altos Labs

1. Retrospective single cell lineage tracing with highly mutable homopolymersNature Communications · 2026
2. Rapid, accurate, and memory-frugal sub-gene-level quantification of probe-based, multiplexed single-cell data2026
3. scRM: A single-cell foundation model trained on scRNA-seq reads2026
4. Regulation, function and evolutionary structure of St18, encoding a Zinc-Finger Transcription Factor, in the oligodendrocyte lineage2026
5. An integrative transcriptomic atlas of ALS and aging skeletal muscle defines shared and distinct molecular programs of degenerationProceedings of the National Academy of Sciences · 2026
6. Empirical-Bayes and Bayesian Hierarchical Modelling for Missingness and Differential Expression in ProteomicsMolecular & Cellular Proteomics · 2026
7. Atlas of cell types and regulatory elements underlying human facial diversityNature Genetics · 2026
8. A cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in diseaseNature Aging · 2026
9. Targeted ATAC-see (tATAC-see): A visual assay for target-specific chromatin profilingJournal of Cell Science · 2026
10. Global and regional DNA methylation patterns in heart failure: a case–control analysisEBioMedicine · 2026
11. Stable bioreactor control reveals acidic pH–driven metabolic reprogramming and mitochondrial dysfunction in human lymphoblastoid cellsCommunications Biology · 2026
12. Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer’s disease neurodegenerationAging · 2026
13. Searching for shared epigenetic clocks: evaluating ultra-conserved markers in a de novo genome assembly of the albacore tunaGeroScience · 2026
14. Trajectories of physical function and biological aging in generally healthy older adults with and without incident invasive cancer over a three-year follow-up: findings from the DO-HEALTH studynpj Aging · 2026
15. Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineageNature Communications · 2026
16. Identification of a DNA methylation signature for worsening of heart failureEuropean Heart Journal · 2025
17. A cross-species single-cell epigenome kidney atlas identifies epithelial cells as a driver of epigenetic aging2026
18. A Physics-based Model Reveals Mechanisms of Epigenetic Memory2026
19. Intrinsic Molecular Timers and a Biphasic Amplitude Limit Regulate the Integrated Stress Response2025
20. Nuclear-lamin-guided plastic positioning and folding of the human genomeCell Reports · 2025