Open Targets

Recent papers from Open Targets

1. The Human Gut Cell Atlas v1.0: A Unified, Community-Built Reference of Cellular Diversity Across the Gut2026
2. Pathway-driven target prioritisation in drug discoveryDrug Discovery Today · 2026
3. Molecular mechanisms and translational prospects in osteoporosisFrontiers in Endocrinology · 2026
4. A data-driven framework reconstructs the molecular continuum of human MASLD progressionNature Metabolism · 2026
5. How many protein pairs can we chemically target?Drug Discovery Today · 2026
6. Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn’s disease pathogenesisNature Genetics · 2026
7. Systematic optimization of PD-L1 and CLDN18.2 CAR-T designs identifies a bicistronic dual-target, double-CD3ζ architecture with enhanced antitumor activity in gastric cancerFrontiers in Immunology · 2026
8. Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosusFrontiers in Immunology · 2026
9. The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications2026
10. An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial functioniScience · 2026
11. The Potential of Digital Twins for Pediatric Rare DiseasesSHILAP Revista de lepidopterología · 2026
12. Association Between Questionnaire‐ and Accelerometer‐Based Physical Activity and Abdominal Aortic Aneurysm IncidenceJournal of the American Heart Association · 2026
13. Ferroptosis as a therapeutic nexus: traditional Chinese medicine interventions in rheumatoid arthritisFrontiers in Immunology · 2026
14. Multiplexed high-content imaging uncovers morphological diversity of lymphocyte activation and dysfunction2026
15. Federated single-cell QTL meta-analysis reveals novel disease mechanisms2026
16. Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNAScience Advances · 2026
17. CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistanceCell Reports Medicine · 2026
18. The molecular cartography of malignant and benign sebaceous tumoursNature Communications · 2025
19. Temporal trends in evidence supporting novel drug target discoveryNature Communications · 2025
20. A next-generation dual guide CRISPR system for genetic interaction library screeningNature Communications · 2025