Acentech (United States)

Recent papers from Acentech (United States)

1. Synthesis of the Substituted 7-Azaindazole Core of TEAD Inhibitor GDC-8025 via Gould–Jacobs Cyclization and Halogen Dance RoutesOrganic Process Research & Development · 2026
2. Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis InfectionACS Infectious Diseases · 2026
3. Evolution of a Synthetic Strategy toward Highly Substituted Isoindolinone Glutarimide FragmentsOrganic Process Research & Development · 2026
4. Enhanced Sampling and Ligandability Assessment to Expand the Repertoire of Potentially Druggable Cryptic PocketsJournal of the American Chemical Society · 2026
5. Combining a Respiration-Based Method with Universal qPCR for 3-Day Rapid Sterility TestingPDA Journal of Pharmaceutical Science and Technology · 2026
6. Discovery ofHighly Selective Noncovalent MacrocyclicPeptide Inhibitors Suppressing Both TMPRSS2 Protease Activity andViral Receptor FunctionJournal of Medicinal Chemistry · 2026
7. Final analysis of the FeDeriCa phase III study: long-term efficacy, safety and pharmacokinetics of the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection, plus chemotherapy, in HER2-positive early breast cancerESMO Open · 2026
8. Priorities of people living with Alzheimer's and care partners: What Matters Most?Alzheimer s & Dementia · 2026
9. Advancing the measurement of caregiver impact: Data collection priorities aligned with caregiver, health technology assessment, and policy stakeholdersJournal of Managed Care & Specialty Pharmacy · 2026
10. Ground-Borne Vibration Prediction in a Metro Depot Using Hybrid Train-Soil-Pile-Structure InteractionsVibration · 2026
11. A single-cell atlas of ulcerative colitis reveals neutrophil–stromal circuits linked to biologic therapy resistanceFrontiers in Immunology · 2026
12. Noncanonical NF-κB pathway driven inflammation across multiple cellular compartments identifies NIK as a therapeutic target for inflammatory bowel diseaseFrontiers in Immunology · 2026
13. Assessing Contribution of Effect in Oncology Combination Therapies: Lessons Learned to Inform and Optimize Future Registrational Trial Designs.2026
14. TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15Proceedings of the National Academy of Sciences · 2026
15. A32-30 Re-Evaluating the Prognostic Value of Symptom Control in Predicting Asthma Attacks: A Patient-Level Analysis of Control Groups of 22 Randomised Trials (ORACLE2)American Journal of Respiratory and Critical Care Medicine · 2026
16. A musician-centered approach to background noise goals for design of practice roomsThe Journal of the Acoustical Society of America · 2025
17. Balancing speech intelligibility and privacy in museums: A perceptual study using spatial sound reproductionThe Journal of the Acoustical Society of America · 2025
18. Complement C3aR deletion does not attenuate degeneration in a tauopathy model or alter acute inflammation-induced gene expression changesCell Reports · 2026
19. 85eP Targeting regulatory T cells in solid tumors: A clinical development analysis of 55 drug candidatesESMO Open · 2026
20. A modular platform for Sterically Masked Activated Cytokines (SMACks)Proceedings of the National Academy of Sciences · 2026