Complement C3aR deletion does not attenuate degeneration in a tauopathy model or alter acute inflammation-induced gene expression changes

Yuanyuan Wang; Shristi Pandey; Martin Weber; Man Kin Choy; Tiffany Wu; Tania Chernov-Rogan; Max Adrian; Ming-Chi Tsai; Hai Ngu; Oded Foreman; Luke Xie; Jesse E. Hanson

doi:10.1016/j.celrep.2026.117313

April 24, 2026Cell ReportsOpen Access

Complement C3aR deletion does not attenuate degeneration in a tauopathy model or alter acute inflammation-induced gene expression changes

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Key Points

This research investigates the effects of C3aR deletion on neurodegeneration and inflammation in a tauopathy model.
Involved a model of tauopathy mice with C3aR deletion
Assessed neurodegeneration and inflammation-related gene expression changes
Evaluated hyperactivity as a behavioral outcome
C3aR deletion did not change levels of tau pathology
No significant alteration in neuroinflammation was observed in tauopathy mice
Hyperactivity levels remained unchanged despite C3aR deletion

Implication

Shows no impact on neurodegeneration in tauopathy mice after C3aR deletion, indicating potential pathway limitations.

Abstract

C3aR deletion does not rescue neurodegeneration or hyperactivity in tauopathy mice C3aR deletion does not affect Tau pathology or neuroinflammation in tauopathy mice

Discussion

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69edaafc4a46254e215b3489 https://doi.org/10.1016/j.celrep.2026.117313

View Full Paper

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Complement C3aR deletion does not attenuate degeneration in a tauopathy model or alter acute inflammation-induced gene expression changes

Key Points

Implication

Abstract

Discussion

Cite This Study

Complement C3aR deletion does not attenuate degeneration in a tauopathy model or alter acute inflammation-induced gene expression changes

Key Points

Implication

Abstract

Discussion

Cite This Study

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