Probiodrug (Germany)

Recent papers from Probiodrug (Germany)

1. A high cell density perfusion process for Modified Vaccinia virus Ankara production: Process integration with inline DNA digestion and cost analysisBiotechnology and Bioengineering · 2021
2. Regulation of influenza A virus mRNA splicing by CLK1Antiviral Research · 2019
3. Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a studyAlzheimer s Research & Therapy · 2018
4. Passive Aβ Immunotherapy: Current Achievements and Future PerspectivesMolecules · 2018
5. Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta FormationMolecules · 2018
6. N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activityBioscience Reports · 2017
7. Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapyJournal of Biological Chemistry · 2017
8. Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patientsAlzheimer s Research & Therapy · 2017
9. Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target OccupancyJournal of Pharmacology and Experimental Therapeutics · 2017
10. Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritisScientific Reports · 2016
11. Neuropeptide Y ( NPY ) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY 1–30fragmentJournal of Neurochemistry · 2016
12. Enhanced Fibril Fragmentation of N‐Terminally Truncated and Pyroglutamyl‐Modified Aβ PeptidesAngewandte Chemie International Edition · 2016
13. Continuous cell lines from the Muscovy duck as potential replacement for primary cells in the production of avian vaccinesAvian Pathology · 2016
14. Characterizing Aging, Mild Cognitive Impairment, and Dementia with Blood-Based Biomarkers and NeuropsychologyJournal of Alzheimer s Disease · 2016
15. Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novelNPY‐cleaving peptidases and potential drug interactions inCNSand PeripheryJournal of Neurochemistry · 2015
16. A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjectsAlzheimer s & Dementia Translational Research & Clinical Interventions · 2015
17. IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymesBiological Chemistry · 2015
18. DPP4 Inhibitors increase differentially the expression of surfactant proteins in Fischer 344 ratsActa Physiologica · 2014
19. Glutaminyl Cyclase in Human Cortex: Correlation with (pGlu)-Amyloid-β Load and Cognitive Decline in Alzheimer's DiseaseJournal of Alzheimer s Disease · 2014
20. Effects of dipeptidyl peptidase-4 inhibition in an animal model of experimental asthma: a matter of dose, route, and timePhysiological Reports · 2013