PamGene (Netherlands)

Recent papers from PamGene (Netherlands)

1. Identification of Kinome Biomarkers and Therapeutic Rescue in cGMP-Linked Retinal Degeneration2026
2. Blood-based kinase activity profiling to predict response to immune checkpoint inhibitors in patients with advanced stage NSCLC: the prospective IOpener studyJournal for ImmunoTherapy of Cancer · 2026
3. Sustained intravitreal dissolution and kinase inhibition by an inhibitory cGMP analogue after its injection as a suspension of a poorly soluble saltBiomedicine & Pharmacotherapy · 2026
4. Abstract 3321: Validating upstream kinase predictions by linking activity to drug target proximityCancer Research · 2026
5. Abstract 5766: Network-level kinase activity associate with differential drug sensitivity in B-Cell lymphoma cell linesCancer Research · 2026
6. Mucosal Kinase Activity and Inflammatory Profiles in Inflammatory Bowel Disease, and in Relation with Tofacitinib ResponseJournal of Crohn s and Colitis · 2025
7. CD28 signaling domain boosts persistence and in vivo anti-tumor activity of stem cell-derived CD19-CAR-NK cellsiScience · 2025
8. The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia modelNature Communications · 2025
9. Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell CarcinomaNeoplasia · 2024
10. Blood based kinase activity profiling to predict response to immune checkpoint inhibitors in patients with advanced stage non-small cell lung cancer: The IOpener study.Journal of Clinical Oncology · 2024
11. Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by NonylphenolEnvironmental Science & Technology · 2024
12. Integrative Kinase Activity Profiling and Phosphoproteomics of rd10 Mouse Retina during cGMP-Dependent Retinal DegenerationInternational Journal of Molecular Sciences · 2024
13. The PKG Inhibitor CN238 Affords Functional Protection of Photoreceptors and Ganglion Cells against Retinal DegenerationInternational Journal of Molecular Sciences · 2023
14. Differentiating Benign from Malignant Thyroid Tumors by Kinase Activity Profiling and Dabrafenib BRAF V600E TargetingCancers · 2023
15. Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubesJournal of Molecular Endocrinology · 2022
16. When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal AntagonistsChemMedChem · 2022
17. Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitorsOncotarget · 2022
18. Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with SunitinibCancers · 2022
19. Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegenerationSocio-Environmental Systems Modeling · 2022
20. Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survivalLife Science Alliance · 2021