Innovative Medicines Initiative

Recent papers from Innovative Medicines Initiative

1. Discovery of Potent 1,2,4-Triazole-Derived HIV Capsid Modulators with Dual-Stage Antiviral Activity via Targeting the Unexplored GTNQ Sub-Pocket Using a Multi-Site Binding StrategyJournal of Medicinal Chemistry · 2026
2. The Somatic Anthropocene: Body, Interoception, and Planetary Crisis2026
3. The Somatic Anthropocene: Body, Interoception, and Planetary Crisis2026
4. Tracing Carbon Sequestration Potential and Chronology of Nitrogen Pollution in a Large Tropical EstuaryACS ES&T Water · 2026
5. Stereoinvertive Cross-Coupling for Trisubstituted Alkenes Enabled by the Sulfoximine Leaving GroupACS Catalysis · 2026
6. High frequency of CD95 ⁺ / CD45RA ⁻ regulatory T cells defines an immunosuppressive profile associated with MDS progressionBritish Journal of Haematology · 2026
7. Clinical and Molecular Characterization of a Rare EGFR cis Compound L833V/H835L Mutation in Non–Small Cell Lung CancerCancer Research Communications · 2026
8. Organizing across disciplines to tackle shared computational challengesPatterns · 2026
9. Associations of Infection Preventionists' Perceptions of Organizational and Direct Leadership with Job Satisfaction and Mental Health: Results of a Cross-Sectional SurveyAmerican Journal of Infection Control · 2026
10. Safe and Sustainable by Design (SSbD) landscape: Mapping state of the art approaches along the innovation process and developing good practicesSustainable Chemistry and Pharmacy · 2026
11. Research Progress on the Structural Biology of Paramyxovirus Polymerase and Its InhibitorsJournal of Medicinal Chemistry · 2026
12. A website calculator to benchmark the carbon footprint of haemodialysisNephrology Dialysis Transplantation · 2026
13. High-Speed Atomic Force Microscopy Reveals Disordered Region-Mediated Structural Plasticity of Anaplastic Lymphoma Kinase Fusion Proteins Induced by InhibitorsACS Nano · 2026
14. Ethics Review of AI research: An approach to reviewing and revising existing governance structuresResearch Ethics · 2025
15. Convergence of computer-aided drug discovery and artificial intelligence: Towards next-generation therapeuticsPharmaceutical Science Advances · 2025
16. Unlocking seagrass germination: divergent roles of strigolactones and smoke-water in Zostera marina (Zosteraceae)Frontiers in Plant Science · 2025
17. The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspectiveeLife · 2025
18. Structure-and Privileged Fragment-Based IterativeOptimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines asNovel HIV-1 NNRTIs with Potent Activity against Drug-ResistantStrains and Favorable Safety ProfilesJournal of Medicinal Chemistry · 2025
19. The class A repeats of Lrp5 are required for normal development of bone, retinal vasculature, and mammary gland in vivoDisease Models & Mechanisms · 2025
20. Probing theDominant Motifs within the HydrophobicChannel Yields Oxadiazole-Containing Diarylpyrimidine Derivativesas Potent HIV-1 Non-Nucleoside Reverse Transcriptase InhibitorsJournal of Medicinal Chemistry · 2025