What question did this study set out to answer?

To investigate the association between Treg profiling and risk of MDS progression.

May 6, 2026British Journal of Haematology0 citations

High frequency of CD95 + / CD45RA − regulatory T cells defines an immunosuppressive profile associated with MDS progression

RVRomain VazquezCentre National de la Recherche Scientifique NDNicolas DeredecCentre National de la Recherche Scientifique IBIsmaël BoussaidCentre National de la Recherche Scientifique

Key Points

To investigate the association between Treg profiling and risk of MDS progression.
Analyzed Treg subpopulations in patients diagnosed with MDS.
Assessed the relationship between Treg profiles and disease progression.
Evaluated the impact of Treg subpopulations on risk stratification and treatment decisions.
Identified a higher frequency of regulatory T cells in patients with MDS progression.
Confirmed that specific Treg profiles indicate an increased risk of disease advancement.

Abstract

Tregs with an increased risk of disease progression independently of the IPSS-R and the IPSS-M. Our findings suggest that profiling Treg subpopulations at diagnosis could improve MDS risk stratification and guide immunosuppressive therapeutic decisions.

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Cite This Study

Vazquez et al. (Mon,) studied this question.

synapsesocial.com/papers/69fa8eca04f884e66b5313a8 https://doi.org/https://doi.org/10.1111/bjh.70504

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