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December 8, 2025BloodOpen Access

Distinct distributions of lymphocyte subsets in myelodysplastic syndrome correlate with risk stratification

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Authors

XLXinguang Liu

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Overview

Cohort study reveals immune dysregulation and altered lymphocyte subsets in MDS patients, suggesting implications for risk stratification.

Key Points

  • To assess lymphocyte subsets in myelodysplastic syndrome (MDS) patients based on risk stratification.
  • Cohort study with 54 newly diagnosed MDS patients and 17 healthy controls.
  • Patients classified using Revised International Prognostic Scoring System (IPSS-R).
  • Multi-parameter flow cytometry used to quantify lymphocyte subsets in bone marrow and peripheral blood.
  • LR-MDS patients showed increased Tfh cells and decreased Tph cells and total B cells in bone marrow.
  • HR-MDS patients exhibited elevated suppressor T lymphocytes, Tfh cells, and NK cells in bone marrow.
  • Significant differences in lymphocyte subsets correlated with MDS risk stratification.

Cite This Study

Xinguang Liu (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d502https://doi.org/10.1182/blood-2025-7361
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Also Consider

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  1. 1From chaos to clarity? decoding the inflammatory profiles in lower-risk MDS2025
  2. 2Bone marrow immune and stromal niche remodeling in myelodysplastic neoplasm patients under erythropoietic therapies by 29-color full-spectrum flow cytometry2025
  3. 3Immunological biomarkers and TARC/CCL17 in myelodysplastic syndrome: Insights into immune microenvironment regulation2025
  4. 4Myelodysplastic neoplasms dissected into indolent, leukaemic and unfavourable subtypes by computational clustering of haematopoietic stem and progenitor cells2024 · 9 citations
  5. 5Low Levels of Natural Killer Cell in Newly Diagnosed Myelodysplastic Syndromes Patients May Confer Poor Prognosis: A Retrospective Cohort Study2024