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April 23, 2026British Journal of Haematology

Not all Tregs in MDS are created equal

Mischa Selig Livius Penter

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Key Points

This commentary discusses the role of different regulatory T cells (Tregs) in myelodysplastic syndromes (MDS) and their association with disease progression.
Analysis of findings from Vazquez et al. regarding Treg populations
Discussion of the CD95+/CD45RA− Treg subset's implications in MDS
Comparative evaluation of immunosuppressive profiles in Tregs associated with MDS progression.
CD95+/CD45RA− Tregs are linked to an immunosuppressive profile in MDS progression.
Higher frequencies of this Treg subset correlate with advanced disease stages.

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Implication

Commentary highlights the unique role of specific Tregs in MDS progression, suggesting targeted immunotherapy implications.

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Cite This Study

Selig et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b8a88ba6daa22dad129 https://doi.org/10.1111/bjh.70503

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1High frequency of <scp>CD95</scp> <sup>+</sup> / <scp>CD45RA</scp> <sup>−</sup> regulatory T cells defines an immunosuppressive profile associated with <scp>MDS</scp> progressionOriginal Research · 2026 · 1 citations
2Interferon-gamma production in the bone marrow of myelodysplastic syndrome patients supports a treg-independent immune-tolerant microenvironment2025
3Myeloid‐derived suppressor cells from tumour‐bearing mice induce the population expansion of <scp>CD19<sup>hi</sup>FcγRIIb<sup>hi</sup></scp> regulatory <scp>B</scp> cells via <scp>PD‐L1</scp>2024 · 3 citations
4Immunological biomarkers and TARC/CCL17 in myelodysplastic syndrome: Insights into immune microenvironment regulation2025
5Low expression of TMSB10 in bone marrow in MDS patients with T cell large granular lymphocytic proliferation is associated with improved immune tolerance status of T cells and disease prognosis: Clinical data and single-cell sequencing analysis2025

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Multiplex spatial analysis reveals increased CD137 expression and m-MDSC neighboring tumor cells in refractory classical Hodgkin Lymphoma2024
Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease2013
Distinct distributions of lymphocyte subsets in myelodysplastic syndrome correlate with risk stratification2025

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