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December 8, 2025BloodOpen Access

Immunosuppressive T-cell landscape in myelodysplastic Neoplasms with TP53 mutations

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Authors

LJLingxu JiangXZXinping ZhouWWWei Wang

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Overview

Flow cytometry reveals T-cell dysfunction in myelodysplastic neoplasms with TP53 mutations, suggesting therapies targeting checkpoints may help.

Key Points

  • This study aims to characterize T-cell dysregulation in the bone marrow of myelodysplastic neoplasms with TP53 mutations.
  • Obtained fresh bone marrow samples from patients with MDS and healthy donors.
  • Performed flow cytometry to assess checkpoint receptor expression on T-cell subsets.
  • Conducted single-cell RNA sequencing on sorted CD3+ T cells to analyze transcriptional profiles.
  • Identified high expression of inhibitory receptors like CTLA4 on T-cells in TP53-mutated MDS patients.
  • Observed reduced naive CD8+ and CD4+ T-cell frequencies in TP53-mutated cases.
  • Found increased regulatory T cells and exhausted CD4+ and CD8+ T-cell populations in TP53-mutated MDS.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d853https://doi.org/10.1182/blood-2025-3833
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Marrow Microenvironmental Pathobiology and Therapeutic Opportunities for TP53-Mutated Myelodysplastic Syndrome/Acute Myeloid Leukemia2026 · 4 citations
  2. 2TP53-mutated MDS and AML: immune dysregulation, tumor microenvironment, and emerging therapeutic strategies2025 · 10 citations
  3. 3Characteristics and prognostic implications of <i>TP53</i> mutations in Chinese patients with myelodysplastic syndromes2025 · 3 citations
  4. 4Genetic and Clinical Features in <i>TP53</i> ‐Mutated Patients With Myelodysplastic Neoplasms: A Retrospective Study Based on Next‐Generation Sequencing Data2026
  5. 5Relationship between myeloma cell genomic alternations and tumor immune microenvironment in bone-related extramedullary disease of newly diagnosed multiple myeloma2025