Taconic (United States)

Recent papers from Taconic (United States)

1. NeoThy™ immune-humanized mice can produce anti-drug antibodies to support immunogenicity assessment for biological drug productsFrontiers in Immunology · 2026
2. Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized miceFrontiers in Immunology · 2026
3. Humanized patient-derived xenografts preserve tumour-specific immune microenvironments2026
4. Validation of Hemoglobin A1c as a Biomarker of Long-Term Glycemic Control in Mouse Models of Obesity and DiabetesPhysiology · 2026
5. Testing the capacity of humanized immune system mice to induce a protective antibody response against the Lyme disease pathogenMicrobiology Spectrum · 2026
6. Abstract 3383: Robust multiplex cytokine profiling in second-generation humanized NOG mice using a 41-plex humanized mouse immune panel: Cross-donor validation and implications for translational oncology studiesCancer Research · 2026
7. Abstract 6978: HIS models lacking FcγR provide increased predictability and facilitate study design for evaluation of immuno-oncology therapeuticsCancer Research · 2026
8. Resolvins modulate haematopoietic stem and progenitor cell dysfunction and neutrophil activation in sickle cell diseaseBlood · 2025
9. Characterization of a factor VIII/immunoglobulin heavy chain μ double-knockout mouse model of hemophilia A for long-term exposure to factor VIII proteinsResearch and Practice in Thrombosis and Haemostasis · 2025
10. The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserveCell Host & Microbe · 2025
11. Improving Students Access to Primary Health Care Through School‐Based Health CentersJournal of School Health · 2024
12. Abstract 4215: Single-cell proteomic characterization of the tumor microenvironment in humanized NOG-EXL patient-derived xenograft (PDX) modelsCancer Research · 2024
13. Abstract 4193: Digital PCR as a novel way to assess chimerism of humanized immune system miceCancer Research · 2024
14. Abstract 5337: Profiling of human CD34+ donors in a myeloid-supportive HIS model provides increased predictability and facilitates study design for evaluation of immuno-oncology therapeuticsCancer Research · 2024
15. Abstract 5338: Evaluation of checkpoint inhibitor efficacy in a humanized immune system mouse model lacking murine Fc gamma receptorsCancer Research · 2024
16. Abstract 5334: Humanization of NOG mice and next-generation NOG strains to induce lineage-specific differentiation of immune cells for assessment of novel immune cell therapies, check point inhibitors, and immune cell engagers for translational immuno-oncology researchCancer Research · 2024
17. Abstract 2836: Assessment of therapeutic antibody efficacy without the interference of murine Fc receptors allows for investigation of human antibody-dependent cellular cytotoxicity mediated by NK cells in the FcResolv™ hIL-15 NOG mouse modelCancer Research · 2024
18. Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG miceJournal for ImmunoTherapy of Cancer · 2024
19. Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 miceVeterinary Pathology · 2024
20. Anxiety-related behaviors without observation of generalized pain in a mouse model of endometriosisFrontiers in Behavioral Neuroscience · 2023