Threshold Pharmaceuticals (United States)

Recent papers from Threshold Pharmaceuticals (United States)

1. Harnessing genotype and phenotype data for population-scale variant classification using large language models and bayesian inferenceHuman Genetics · 2025
2. ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Nab-Paclitaxel in Patients with Advanced Solid TumorsCancer Research Communications · 2024
3. A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug‐Drug Interaction Potential of the Cytotoxic Prodrug EvofosfamideCPT Pharmacometrics & Systems Pharmacology · 2018
4. A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple MyelomaClinical Cancer Research · 2018
5. Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinomaJCI Insight · 2018
6. Hypoxia-Targeting Drug Evofosfamide (TH-302) Enhances Sunitinib Activity in Neuroblastoma Xenograft ModelsTranslational Oncology · 2018
7. Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in MiceCancer Research · 2018
8. Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical studyNeuro-Oncology · 2018
9. Cabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor–Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group TrialJournal of Clinical Oncology · 2017
10. A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor ModelTranslational Oncology · 2017
11. Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo StudiesAntioxidants and Redox Signaling · 2017
12. Utilisation of supplemented l -carnitine for fuel efficiency, as an antioxidant, and for muscle recovery in Labrador retrieversJournal of Nutritional Science · 2017
13. Hypoxia Imaging with PET Correlates with Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma ModelsTomography · 2016
14. Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver CancerClinical Cancer Research · 2016
15. MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer XenograftsPLoS ONE · 2016
16. Phase I study of evofosfamide, an investigational hypoxia‐activated prodrug, in patients with advanced leukemiaAmerican Journal of Hematology · 2016
17. Utilizing social media to support community integrationAmerican Journal of Psychiatric Rehabilitation · 2016
18. Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer modelsCancer Biology & Therapy · 2016
19. Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia ModelsClinical Cancer Research · 2015
20. Repeatability of hypoxia PET imaging using [18F]HX4 in lung and head and neck cancer patients: a prospective multicenter trialEuropean Journal of Nuclear Medicine and Molecular Imaging · 2015