Medicines Discovery Catapult

Recent papers from Medicines Discovery Catapult

1. Three-dimensional mapping of human lung fibrosis identifies spatial coupling between tissue microarchitecture and maladaptive repair states2026
2. Beyond Cytotoxic Payloads for Antibody Drug Conjugates─A Medicinal Chemistry PerspectiveBioconjugate Chemistry · 2026
3. Time for Precision: Rethinking antimicrobial use to combat AMR globallyCambridge Prisms Antimicrobial Resistance · 2026
4. Regulatory momentum for new approach methodologies (NAMs) in medicines development: from vision to implementationCurrent Opinion in Toxicology · 2026
5. Combining Artificial Intelligence and Human Expertise in Pursuit of Novel PolQ InhibitorsACS Omega · 2026
6. Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom—Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals ProgrammeAlzheimer s & Dementia · 2026
7. Clinical trials in depression: Integrated collection across EU and US registriesWellcome Open Research · 2026
8. Abstract 4633: Theranostic evaluation of 68Ga-PMSA, 177Lu PSMA therapy, and biomarker guided immunotherapy and DDR inhibitor combinations in LNCaP prostate cancer xenograftsCancer Research · 2026
9. Abstract 7370: End-to-end in vitro and in vivo evaluation of radiopharmaceuticals in patient-derived modelsCancer Research · 2026
10. Improvements in high-yield detection and localisation of cholesterol in murine brains using water cluster beam secondary ion mass spectrometryAnalytical and Bioanalytical Chemistry · 2026
11. Acridinium Chemiluminogenic Labels—Synthesis, Analytical Performance, and Mechanism of Light Generation—A Comparison in View of Biomedical DiagnosticsMolecules · 2026
12. MC4R methylation and antipsychotic-related metabolic changes in early psychosis: findings from two prospective cohortsSchizophrenia Research · 2026
13. Current Insights and Future Directions of Multiomic and Spatial-Omic Analysis in Non–Small Cell Lung CancerJCO Precision Oncology · 2026
14. Effect of microbubble-assisted gemcitabine delivery with repeated ultrasound exposure in a pancreatic cancer organ-on-a-chip modelScientific Reports · 2025
15. Unmet diagnostic needs in cystic fibrosis infections and exacerbations: focus groups to inform target product profiles (TPPs)NIHR Open Research · 2025
16. The development of patient-focused diagnostic target product profiles for detection of infection and exacerbation in people with cystic fibrosisNIHR Open Research · 2025
17. The development of patient-focused diagnostic target product profiles for detection of infection and exacerbation in people with cystic fibrosisNIHR Open Research · 2025
18. Anti-progestin therapy targets hallmarks of breast cancer riskNature · 2025
19. A novel cannabidiol:tetramethylpyrazine cocrystal (CBD:TMP, ART12.11) improves the efficacy and bioavailability of cannabidiol in reducing stress-induced depressive and anxiety symptomsProgress in Neuro-Psychopharmacology and Biological Psychiatry · 2025
20. Multiplexed proximity labelling proteomics identifies a non-canonical Bcl-2 family interactome associated with apoptotic priming2025