ToolGen (South Korea)

Recent papers from ToolGen (South Korea)

1. CRISPR/Cas9-mediated SLC12A3 gene knock-in restores molecular and functional defects in Gitelman syndrome hiPSC-derived kidney organoidsStem Cell Research & Therapy · 2026
2. Age- and sex-adjusted genomic differences between Korean and Beat AML cohortsBlood Advances · 2026
3. A novel mouse model of cerebral microbleeds by targeted Col4a1 editing in adult brain microvesselsBrain · 2026
4. Automation-assisted human skin-on-a-chip for modeling ultraviolet-induced injury and evaluating photoprotective and regenerative modalitiesLab on a Chip · 2026
5. Abstract 4945: Distinct colorectal cancer tumor cell subtypes revealed by single-cell and spatial transcriptomicsCancer Research · 2026
6. Abstract 7829: Fragmented plasma cfDNA as a prognostic and surveillance biomarker for locoregional recurrence in oral squamous cell carcinoma.Cancer Research · 2026
7. Energy-Metabolism-Enhancing Probiotics Enhance the Therapeutic Response to a Glucagon-like Peptide-1 Receptor AgonistNutrients · 2026
8. Targeted KEAP1 Disruption Enhances Antioxidant Defense And Mesenchymal Stromal Cell Therapy For Chronic Limb-threatening IschemiaMolecular Therapy · 2026
9. Abstract PS2-10-12: Perioperative minimal residual disease monitering using a tumor-informed ctDNA assay in stage II-III breast cancerClinical Cancer Research · 2026
10. CRISPR/Cas9-based SLC12A3 gene knock in: a model for cellular feature analysis in Gitelman syndromeKidney Research and Clinical Practice · 2026
11. Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli ‐Based Tri‐SelectionAdvanced Science · 2026
12. Two-in-one protein tag enables the soluble expression and calcium-dependent purification of single-chain antibody fragmentsCommunications Biology · 2026
13. DOS209 enhances metabolic protection: a randomized double-blind placebo-controlled trialMolecular & Cellular Toxicology · 2025
14. Pan-Cancer Single-Cell RNA Sequencing Analysis Refines Multi-Origin Monocyte and Macrophage LineagesCancer Immunology Research · 2025
15. Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated MechanotransductionAdvanced Science · 2025
16. Modulating the strigolactone pathway to optimize tomato shoot branching for vertical farmingJournal of Integrative Plant Biology · 2025
17. Targeted genome editing of ZKSCAN3 mitigates the neurotoxicity caused by mutant HTT (huntingtin) in a Huntington disease animal model and three-dimensional cell culture of Huntington diseaseAutophagy · 2025
18. Novel mouse model of cerebral microbleeds created by Crispr/Cas9-mediated Col4a1 deletion in adult brain microvessels2025
19. Mechanical environment afforded by engineered polymer hydrogel critically regulates survival of neural stem cells transplanted in the injured spinal cord via Piezo1-mediated mechanotransduction2025
20. CRISPR-Cas9 knockout of DGKα/ζ improves the anti-tumor activities of TAG-72 CAR-T cells in ovarian cancerMolecular Therapy Oncology · 2025