Heidelberg Pharma (Germany)

Recent papers from Heidelberg Pharma (Germany)

1. Physicochemical and Metabolic Optimization of NAMPT Inhibitors Enables Effective Antibody–Drug Conjugates for Liquid and Solid TumorsACS Bio & Med Chem Au · 2026
2. Funktionalisierung von Peptiden auf der festen Phase im späten SynthesestadiumAngewandte Chemie · 2026
3. Abstract 5639: HDP-103, a PSMA targeting amanitin-based ADC, is efficacious even in difficult to treat patient derived xenograft models with heterogenous PSMA expressionCancer Research · 2026
4. Abstract 5604: TAK-188, an antibody-drug conjugate with a novel amanitin payload, disrupts immune suppression and leads to potent anti-tumor immunity through selective depletion of CCR8+ intratumoral regulatory T-cellsCancer Research · 2026
5. Amanitin-Based Fc-Small Molecule Drug Conjugates with Non-Cleavable Linker: A Novel Therapeutic Strategy for Prostate Cancer Targeted TherapyMolecular Cancer Therapeutics · 2026
6. pH-Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma.2026
7. Thermally induced neuronal plasticity in the hypothalamus mediates heat toleranceNature Neuroscience · 2024
8. Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic CancerMolecular Cancer Therapeutics · 2024
9. Early Silicone Oil Opacification in the Absence of Emulsification Is Caused by an Increased Level of Silicone DioxideRetina · 2024
10. ETx-22, a Novel Nectin-4–Directed Antibody–Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4–Expressing TumorsCancer Research Communications · 2024
11. TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemiaThe EMBO Journal · 2024
12. Site‐specific modification of native IgGs with flexible drug‐loadChemBioChem · 2024
13. TwinF interface inhibitor FP802 prevents retinal ganglion cell loss in a mouse model of amyotrophic lateral sclerosisActa Neuropathologica Communications · 2024
14. NL2IBE – Ontology-controlled Transformation of Natural Language into Formalized Engineering Artefacts2024
15. Abstract CT067: The anti-BCMA antibody-drug conjugate HDP-101 with a novel amanitin payload shows promising initial first in human results in relapsed multiple myelomaCancer Research · 2024
16. Abstract LB059: Multimeric linker-exatecan-based ADC targeting guanylyl cyclase C (GCC) as novel therapeutic modality for treatment of colorectal cancerCancer Research · 2024
17. Dual-Capped Helical Interface MimicsJournal of the American Chemical Society · 2024
18. Abstract 1865: HDP-102 - a CD37-targeting Amanitin-based-ADC for the treatment of NHL - non-clinical data packageCancer Research · 2024
19. Abstract 7183: Liver toxicity of amanitin-based antibody drug conjugates (ATACs) is caused by unspecific uptake of the ATAC into liver cellsCancer Research · 2024
20. The Effects of Myo-Inositol and D-Chiro-Inositol in a Ratio 40:1 on Hormonal and Metabolic Profile in Women with Polycystic Ovary Syndrome Classified as Phenotype A by the Rotterdam Criteria and EMS-Type 1 by the EGOI CriteriaGynecologic and Obstetric Investigation · 2024