Ichimaru Pharcos (Japan)

Recent papers from Ichimaru Pharcos (Japan)

1. An Improved Brain-Penetrating Nanoformulation of the VIPR2 Antagonist Peptide KS-133 for Treating Cognitive Impairment in SchizophreniaBiological and Pharmaceutical Bulletin · 2026
2. Epigenetic regulation of hyaluronan degradation and melanogenesis by Kawarayomogin I and II from Artemisia capillaris via miR-486-5p and miR-141-3p.2026
3. Induction of Melanin Synthesis by Pueraria lobata Leaves in B16 Murine Melanoma Cells and Three-Dimensional Human Skin EquivalentBiological and Pharmaceutical Bulletin · 2025
4. A Next-Generation Brain-Targeting Peptide: KS-487 Rivals Angiopep-2 in BBB Penetration with Enhanced SelectivityBioconjugate Chemistry · 2025
5. Peony Root Extract Controls AGE–RAGE Interaction, Suppresses AGE Formation, and Reduces Skin DullnessCosmetics · 2025
6. Therapeutic Potential of Brain-Penetrating Nanoparticles Containing a Selective Vip Receptor 2 (Vipr2) Antagonist Peptide for SchizophreniaThe International Journal of Neuropsychopharmacology · 2025
7. The aqueous extracts of Inonotus obliquus (Chaga) augment host defense against Listeria monocytogenes infectionBioscience Biotechnology and Biochemistry · 2025
8. A novel drug target VIPR2 to regulate migration and proliferation in breast cancerFolia Pharmacologica Japonica · 2025
9. Artemisia capillaris with two novel active compounds, Kawarayomogin I and II, inhibits HYBID (KIAA1199) expression as well as hyaluronic acid degradationScientific Reports · 2025
10. Impact of Structural Empowerment on the Work Engagement of Non-managerial Nurses, by Years of ExperienceJournal of Japan Academy of Nursing Science · 2025
11. Salmon nasal cartilage proteoglycan up-regulates Listeria monocytogenes-mediated immune response in miceCurrent Research in Microbial Sciences · 2025
12. KS‐133/KS‐487 Nanoparticles Exhibit Potent Antitumor Effects through Synergistic LRP1 Targeting and VIPR2 Inhibition: Therapeutic Nanoarchitectonics for Solid TumorsAdvanced Therapeutics · 2024
13. Mentha piperita leaf extract suppresses the release of ATP from epidermal keratinocytes and reduces dermal thinning as well as wrinkle formationInternational Journal of Cosmetic Science · 2024
14. Cyclic Peptides KS-133 and KS-487 Multifunctionalized Nanoparticles Enable Efficient Brain Targeting for Treating SchizophreniaJACS Au · 2024
15. The efficacy and tolerability of proteoglycan F in the treatment of knee osteoarthritis: A prospective, randomized, double-blind controlled trialOsteoarthritis and Cartilage Open · 2024
16. Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cellsJournal of Pharmacological Sciences · 2024
17. The cancer‐associated glycosyltransferase GnT‐V ( MGAT5 ) recognizes the N‐glycan core via residues outside its catalytic pocketFEBS Letters · 2023
18. The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibodyPLoS ONE · 2023
19. Juniper berry extract containing Anthricin and Yatein suppresses lipofuscin accumulation in human epidermal keratinocytes through proteasome activation, increases brightness and decreases spots in human skinInternational Journal of Cosmetic Science · 2023
20. Nanoformulation of the K-Ras(G12D)-inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumorsScientific Reports · 2023