Heat Biologics (United States)

Recent papers from Heat Biologics (United States)

1. Encephalitic alphavirus infection induces long-term humoral and cell-mediated responses in seropositive participants from PanamaPLoS neglected tropical diseases · 2026
2. Enhancing HIV-1-specific CAR-T cell functional activity by treatment with a novel cytokine-based scaffold with IL-15 superagonist and TGF-β-neutralizing activityJournal of Virology · 2026
3. Bacterial bunker-busters: Novel Immunotherapeutics against Pneumonic Plague 2253158The Journal of Immunology · 2026
4. Abstract 1629: An innovative approach to improve bispecific T-cell engagers for solid tumor therapyCancer Research · 2026
5. IL-7/IL-15/IL-21 cytokine-fusion scaffold generates highly functional CAR T cells enriched in long-lived T memory stem cellsScience Advances · 2026
6. TGF-βRII/IL-15 immunotherapeutic complex targets exhausted CD8 ⁺ T-cell subsets in lymph nodes and tumorsJournal for ImmunoTherapy of Cancer · 2025
7. Generation of HIV- and CD19-Specific TSCM CAR-T Cells by a Novel Cytokine-Based Scaffold 2319The Journal of Immunology · 2025
8. Development of analytical methods for detection of anti-drug antibodies neutralizing IL-15 and TGF-β RII activityJournal of Immunoassay and Immunochemistry · 2025
9. An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levelsSHILAP Revista de lepidopterología · 2025
10. Bleed treatment with eptacog beta (rFVIIa) results in a low incidence of rebleeding in adult and adolescent patients with haemophilia A or B with inhibitorsHaemophilia · 2024
11. A “Prime and Expand” strategy using the multifunctional fusion proteins to generate memory-like NK cells for cell therapyCancer Immunology Immunotherapy · 2024
12. Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in miceAging Cell · 2023
13. A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in miceFrontiers in Immunology · 2023
14. Secreted heat shock protein gp96-Ig and OX40L-Fc combination vaccine enhances SARS-CoV-2 Spike (S) protein-specific B and T cell immune responsesVaccine X · 2022
15. Eptacog beta efficacy and safety in the treatment and control of bleeding in paediatric subjects (<12 years) with haemophilia A or B with inhibitorsHaemophilia · 2022
16. Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cellsMolecular Therapy · 2022
17. Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx developmentDevelopmental Dynamics · 2021
18. The safety of activated eptacog beta in the management of bleeding episodes and perioperative haemostasis in adult and paediatric haemophilia patients with inhibitorsHaemophilia · 2021
19. PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitorsHaemophilia · 2021
20. A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer ImmunotherapyCancer Immunology Research · 2021