Insilico Medicine (United States)

Recent papers from Insilico Medicine (United States)

1. Recent advances in the discovery of PKMYT1-targeting drugs: a patent review (2021–2025)Expert Opinion on Therapeutic Patents · 2026
2. From Prompt to Drug: Toward Pharmaceutical SuperintelligenceACS Central Science · 2026
3. Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of TumorsJournal of Medicinal Chemistry · 2025
4. Navigating the USPTO’s AI inventorship guidance in AI-driven drug discoveryJournal of Law and the Biosciences · 2025
5. Molecular LEGION: Latent Enumeration, Generation, Integration, Optimization and Navigation. A case study of incalculably large chemical space coverage around the NLRP3 target2025
6. From Clock to Clock: Therapeutic Target Discovery for Aging and Age-Related DiseasesAgeing Research Reviews · 2025
7. AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging.2025
8. Rational Design and Identification of ISM7594 as a Tissue-Agnostic FGFR2/3 InhibitorJournal of Medicinal Chemistry · 2025
9. AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal CarcinomaInternational Journal of Molecular Sciences · 2025
10. DORA AI Scientist: Multi-agent Virtual Research Team for Scientific Exploration Discovery and Automated Report Generation2025
11. Design, Synthesis, and Biological Evaluation of Novel Orally Available Covalent CDK12/13 Dual Inhibitors for the Treatment of TumorsJournal of Medicinal Chemistry · 2025
12. Discovery of Pyrrolopyrazine Carboxamide Derivatives as Potent and Selective FGFR2/3 Inhibitors that Overcome Mutant ResistanceJournal of Medicinal Chemistry · 2025
13. AI-Driven Toolset for IPF and Aging Research Associates Lung Fibrosis with Accelerated Aging2025
14. Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitorNature Biotechnology · 2024
15. Organization of the Proteostasis Network of Membraneless Organelles2024
16. Graph Transformer Foundation Model for modeling ADMET properties2024
17. TNIK’s emerging role in cancer, metabolism, and age-related diseasesTrends in Pharmacological Sciences · 2024
18. Abstract PO2-05-08: ISM5043, a novel, selective KAT6 inhibitor for the treatment of advanced and refractory ER+ breast cancerCancer Research · 2024
19. Rapamycin in the context of Pascal’s Wager: generative pre-trained transformer perspectiveOncoscience · 2022
20. Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adultsAging · 2022