AFFiRiS (Austria)

Recent papers from AFFiRiS (Austria)

1. Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington diseaseNeurobiology of Disease · 2023
2. Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse ModelsMolecular Cancer Therapeutics · 2022
3. Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson’s Disease: A Randomized, Placebo-Controlled, Phase 1 StudyJournal of Parkinson s Disease · 2021
4. A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9European Journal of Clinical Pharmacology · 2021
5. A Phase 1 Randomized Trial of Specific Active α‐Synuclein Immunotherapies PD01A and PD03A in Multiple System AtrophyMovement Disorders · 2020
6. Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's diseaseNeurobiology of Disease · 2020
7. NMR Characterization of Surface Receptor Protein Interactions in Live Cells Using Methylcellulose HydrogelsAngewandte Chemie International Edition · 2019
8. NMR Characterization of Surface Receptor Protein Interactions in Live Cells Using Methylcellulose HydrogelsAngewandte Chemie · 2019
9. Effects of single and combined immunotherapy approach targeting amyloid β protein and α‐synuclein in a dementia with Lewy bodies–like modelAlzheimer s & Dementia · 2019
10. Quantitative in vitro and in vivo models to assess human IgE B cell receptor crosslinking by IgE and EMPD IgE targeting antibodiesJournal of Immunological Methods · 2017
11. The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP miceEuropean Heart Journal · 2017
12. Osteopontin is a key player for local adipose tissue macrophage proliferation in obesityMolecular Metabolism · 2016
13. Common dysregulated pathways in obese adipose tissue and atherosclerosisCardiovascular Diabetology · 2016
14. Osteopontin affects macrophage polarization promoting endocytic but not inflammatory propertiesObesity · 2016
15. Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin CleavagePLoS ONE · 2016
16. Identification of Matrix Metalloproteinase-12 as a Candidate Molecule for Prevention and Treatment of Cardiometabolic DiseaseMolecular Medicine · 2016
17. Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer’s diseaseJournal of Neuroinflammation · 2015
18. Active immunization therapies for Parkinson's disease and multiple system atrophyMovement Disorders · 2015
19. Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophyMolecular Neurodegeneration · 2015
20. Tailoring the Antibody Response to Aggregated Aß Using Novel Alzheimer-VaccinesPLoS ONE · 2015