Avacta (United Kingdom)

Recent papers from Avacta (United Kingdom)

1. A phase Ia/Ib trial of FAP-Dox (AVA6000), a fibroblast activation protein (FAP)–released doxorubicin peptide drug conjugate in patients with FAP-positive solid tumors and activity against salivary gland cancers.Journal of Clinical Oncology · 2026
2. Abstract 5656: Characterization and translational development of novel pre|CISION® technology compounds delivering complementary dual payloads to the tumor microenvironment following FAP cleavage.Cancer Research · 2026
3. Generating and validating renewable affimer protein binding reagents targeting SH2 domainsScientific Reports · 2024
4. High-Throughput profiling of SH2 domains using Affimer reagents: unravelling protein interaction networks2024
5. Safety, tolerability, and pharmacokinetics of Aurora kinase B inhibitor AZD2811: a phase 1 dose-finding study in patients with advanced solid tumoursBritish Journal of Cancer · 2023
6. Rab11-FIP1/RCP Functions as a Major Signalling Hub in the Oncogenic Roles of Mutant p53 in CancerFrontiers in Oncology · 2021
7. In vitro characterisation and clinical evaluation of the diagnostic accuracy of a new antigen test for SARS-CoV-2 detection2021
8. Enrichment and Liquid Chromatography–Mass Spectrometry Analysis of Trastuzumab and Pertuzumab Using Affimer ReagentsAnalytical Chemistry · 2021
9. Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1Cells · 2021
10. RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric siteNature Communications · 2021
11. Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membraneCell Death and Disease · 2021
12. RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site2020
13. Affimers as an alternative to antibodies for protein biomarker enrichmentProtein Expression and Purification · 2020
14. L-bodies are novel RNA-protein condensates driving RNA transport in Xenopus oocytes2020
15. Affimers as Anti-Idiotypic Affinity Reagents for Pharmacokinetic Analysis of BiotherapeuticsBioTechniques · 2019
16. Serum IgE cross‐reactivity between fish and chicken meats in dogsVeterinary Dermatology · 2018
17. Superchiral Plasmonic Phase Sensitivity for Fingerprinting of Protein Interface StructureACS Nano · 2017
18. Extensive protein hydrolyzation is indispensable to prevent IgE-mediated poultry allergen recognition in dogs and catsBMC Veterinary Research · 2017
19. Affimer proteins are versatile and renewable affinity reagentseLife · 2017
20. Co‐sensitization and cross‐reactivity between related and unrelated food allergens in dogs – a serological studyVeterinary Dermatology · 2016