Kringle Pharma (Japan)

Recent papers from Kringle Pharma (Japan)

1. Intrathecal Recombinant Human Hepatocyte Growth Factor for Acute Cervical Spinal Cord Injury with AIS Grade A at 72 h Post-Injury: Phase III Study of Safety and EfficacyJournal of Neurotrauma · 2026
2. Tie2-enriched nucleus pulposus cell transplantation enables severity-independent disc repair in a canine model with induced and controlled disc degeneration severitynpj Regenerative Medicine · 2026
3. Development of novel anti-cancer drug by “locking inhibition” of amino acid transporter LAT1.Journal of Clinical Oncology · 2026
4. Phase I/II Study of Intrathecal Administration of Recombinant Human Hepatocyte Growth Factor in Patients with Acute Spinal Cord Injury: A Double-Blind, Randomized Clinical Trial of Safety and EfficacyJournal of Neurotrauma · 2020
5. Safety, Tolerability, and Pharmacodynamics of Intrathecal Injection of Recombinant Human HGF (KP‐100) in Subjects With Amyotrophic Lateral Sclerosis: A Phase I TrialThe Journal of Clinical Pharmacology · 2018
6. The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathwayInternational Journal of Oncology · 2016
7. Pharmacokinetics and Pharmacodynamics following Intravenous Administration of Recombinant Human Hepatocyte Growth Factor in Rats with Renal InjuryPharmacology · 2014
8. Interruption of the HGF paracrine loop by NK4, an HGF antagonist, reduces VEGF expression of CT26 cellsOncology Reports · 2013
9. Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout MiceInternational Journal of Tryptophan Research · 2013
10. Dissociation of c‐Met phosphotyrosine sites in human cells in response to mouse hepatocyte growth factor but not human hepatocyte growth factor: the possible roles of different amino acids in different speciesCell Biochemistry and Function · 2012
11. Hepatocyte growth factor overexpression in the nervous system enhances learning and memory performance in miceJournal of Neuroscience Research · 2012
12. Identification of Mannose Receptor as Receptor for Hepatocyte Growth Factor β-ChainJournal of Biological Chemistry · 2012
13. Improvement of Sepsis by Hepatocyte Growth Factor, an Anti-Inflammatory Regulator: Emerging Insights and Therapeutic PotentialGastroenterology Research and Practice · 2012
14. Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord InjuryPLoS ONE · 2011
15. Recombinant human hepatocyte growth factor (HGF), but not rat HGF, elicits glomerular injury and albuminuria in normal rats via an immune complex‐dependent mechanismClinical and Experimental Pharmacology and Physiology · 2011
16. Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusionJournal of Neuroscience Research · 2010
17. Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrusMolecular Brain · 2010
18. Structure of Pleiotrophin- and Hepatocyte Growth Factor-binding Sulfated Hexasaccharide Determined by Biochemical and Computational ApproachesJournal of Biological Chemistry · 2010
19. Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25 ⁺ Foxp3 ⁺ regulatory T cellsProceedings of the National Academy of Sciences · 2010
20. Antiapoptotic and antiautophagic effects of glial cell line‐derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in ratsJournal of Neuroscience Research · 2010