Med Discovery (Switzerland)

Recent papers from Med Discovery (Switzerland)

1. Ultrasensitive detection of alpha-synuclein oligomers in human plasma using optimized nano-QuICnpj Parkinson s Disease · 2026
2. Tobemstomig, a novel bispecific antibody, preferentially blocks PD-1 and LAG-3 on CD8 TILs to expand stem-like T-cells for sustained tumor controlCancer Research Communications · 2026
3. Can we refute a role for infections in Alzheimer's disease pathogenesis?Alzheimer s & Dementia · 2026
4. Inhibition of Growth and Induction of Apoptosis of Human Prostate Cancer Cells by Enzymatic Blockage of KallikreinsProstate Cancer · 2026
5. Fragment-based discovery enables direct targeting of the melanoma oncogene MITFNature Communications · 2025
6. Xylanolytic metabolism is regulated by coordination of transcription factors XynR and XylR in extremely thermophilic CaldicellulosiruptoralesApplied and Environmental Microbiology · 2025
7. Identification of potent biparatopic antibodies targeting FGFR2 fusion–driven cholangiocarcinomaJournal of Clinical Investigation · 2025
8. Selective haematological cancer eradication with preserved haematopoiesisNature · 2024
9. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistanceNature Communications · 2024
10. Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapyThe Journal of Experimental Medicine · 2023
11. Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffoldsProtein Science · 2023
12. RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAFV600E metastatic colorectal cancerNature Medicine · 2022
13. Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cellsEuropean Journal of Immunology · 2020
14. The Immune Checkpoint Modulator OX40 and Its Ligand OX40L in NK-Cell Immunosurveillance and Acute Myeloid LeukemiaCancer Immunology Research · 2018
15. Secretory IgA as a vaccine carrier for delivery of HIV antigen to M cellsEuropean Journal of Immunology · 2014
16. Role of secretory IgA in the mucosal sensing of commensal bacteriaGut Microbes · 2014
17. An allosteric anti-hepsin antibody derived from a constrained phage display libraryProtein Engineering Design and Selection · 2012
18. Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington diseaseJournal of Clinical Investigation · 2011
19. Major Role of Human KLK14 in Seminal Clot LiquefactionJournal of Biological Chemistry · 2008
20. Activation and enzymatic characterization of recombinant human kallikrein 8Biological Chemistry · 2006