Afraxis (United States)

Recent papers from Afraxis (United States)

1. A Small Molecule Spinogenic Compound Enhances Functional Outcome and Dendritic Spine Plasticity in a Rat Model of Traumatic Brain InjuryJournal of Neurotrauma · 2018
2. PDE4D regulates Spine Plasticity and Memory in the Retrosplenial CortexSHILAP Revista de lepidopterología · 2018
3. Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)Scientific Reports · 2017
4. Early life diet containing prebiotics and bioactive whey protein fractions increased dendritic spine density of rat hippocampal neuronsInternational Journal of Developmental Neuroscience · 2016
5. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p K a Polar MoietyACS Medicinal Chemistry Letters · 2015
6. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agentsBreast Cancer Research · 2015
7. Group I Paks as therapeutic targets in NF2-deficient meningiomaOncotarget · 2015
8. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescenceProceedings of the National Academy of Sciences · 2014
9. FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated SchwannomasJournal of Biological Chemistry · 2013
10. Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486Proceedings of the National Academy of Sciences · 2013
11. p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer ModelCancer Research · 2012