Table S9 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 demonstrates potential as a small-molecule tubulin destabilizer for glioblastoma treatment.
• KEY EVIDENCE: Tests reveal enhanced cellular permeability of RGN6024 in brain tissues.
• APPROACH: The study analyzes the effects of RGN6024 on tubulin dynamics in glioblastoma models.
• SIGNIFICANCE: This research may open new pathways for therapeutic strategies against aggressive brain tumors.