Supplementary Fig. S12 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer

Mutation burden varies with intestinal metaplasia, influencing gastric cancer outcomes and treatment options.
Key evidence shows a significant difference in mutation rates between intestinal metaplasia of intestinal-type and diffuse-type gastric cancer.
Comparative genomic analysis focuses on the mutation burden related to intestinal metaplasia in gastric cancer subtypes.
The findings suggest potential implications for individualized therapies targeting specific gastric cancer characteristics.

Comparison of mutation burden according to IM in IGC and DGC.

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Xu et al. (Fri,) studied this question.

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Supplementary Fig. S4 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025