A novel visible-light-driven method for the trifluoroacetylation of azauracils was reported, utilizing oxygen as the oxidant and a masked trifluoroacetyl reagent as the radical precursor. This eco-friendly approach eliminates the need for expensive catalysts, transition metals, and additional additives, offering a straightforward, efficient, and scalable solution. The method demonstrates excellent functional group tolerance and versatility, making it ideal for late-stage modifications of a wide range of bioactive molecules. This advancement not only improves the synthetic accessibility of trifluoroacetylated compounds but also supports the principles of sustainable chemistry.
An et al. (Fri,) studied this question.