Metabolic Strategies of Treg Cells in the Tumor Microenvironment: Implications for Immune Metabolism-Based Precision Medicine

firstₚage Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Metabolic Strategies of Treg Cells in the Tumor Microenvironment: Implications for Immune Metabolism-Based Precision Medicine † by Devendra Kumar MishraDevendra Kumar Mishra SciProfiles Scilit Preprints. org Google Scholar 1, *, Sandeep YadavSandeep Yadav SciProfiles Scilit Preprints. org Google Scholar 1, Sumit ChaudhariSumit Chaudhari SciProfiles Scilit Preprints. org Google Scholar 2, Ila DixitIla Dixit SciProfiles Scilit Preprints. org Google Scholar 2, Lavkush TiwariLavkush Tiwari SciProfiles Scilit Preprints. org Google Scholar 2, Khalid Abdul WaheedKhalid Abdul Waheed SciProfiles Scilit Preprints. org Google Scholar 2, Shubham ShuklaShubham Shukla SciProfiles Scilit Preprints. org Google Scholar 3 and Savita UpadhyaySavita Upadhyay SciProfiles Scilit Preprints. org Google Scholar 2 1 RGS College of Pharmacy, Lucknow 226203, Uttar Pradesh, India 2 Ambekeshwar Institute of Pharmaceutical Sciences, Lucknow 226201, Uttar Pradesh, India 3 BBAU Satellite Centre, Babasaheb Bhimrao Ambedkar University, Amethi 227413, Uttar Pradesh, India * Author to whom correspondence should be addressed. † Presented at the 4th International Electronic Conference on Cancers, 6–8 March 2024; Available online: https: //sciforum. net/event/IECC2024. Proceedings 2024, 100 (1), 22; https: //doi. org/10. 3390/proceedings2024100022 Published: 27 May 2024 Download keyboardₐrrowdown Download PDF Download PDF with Cover Download XML Download Epub Download Supplementary Material Versions Notes Keywords: tumor microenvironment (TME) ; warburg effect; regulatory T (Treg) cells; immune metabolism-based precision medicine In recent years, the complex relationship between immune cells and the area around the tumour has become an important factor in how cancer grows and how well treatment works. Regulatory T cells (Tregs), a specific type of CD4+ T cell, are very important for keeping the immune system in balance, but tumours can also use them to weaken the immune system. To improve precision medicine approaches in cancer immunotherapy, we need to know more about the metabolic strategies used by Tregs in the tumour microenvironment. This review looks at the changes that Tregs' metabolism goes through when they enter a tumour, showing how their metabolism is different from that of effector T cells. We look into how Tregs use glycolysis, oxidative phosphorylation, and fatty acid metabolism to help them stay alive and keep other cells from attacking. We also talk about how the metabolism of Treg cells changes in response to environmental cues and immune checkpoint inhibitors. We also talk about what Treg metabolic plasticity means for the development of new strategies in immune metabolism-based precision medicine. In conclusion, this review shows how important it is to understand how Treg cells work in the area around a tumour because it could lead to more personalised and effective cancer immunotherapy. The new information from these studies opens up new ways to treat cancer that might tip the balance in favour of the body's immune system. This could start a new era in the fight against cancer. Supplementary MaterialsThe following supporting information can be downloaded at: https: //www. mdpi. com/article/10. 3390/proceedings2024100022/s1, Conference Poster: Metabolic Strategies of Treg Cells in the Tumor Microenvironment: Implications for Immune Metabolism-Based Precision Medicine. Author ContributionsD. K. M. , S. Y. , S. C. , I. D. , L. T. , K. A. W. , S. S. and S. U.: conceptualization, methodology, data collection, writing—original draft preparation; D. K. M. , S. Y. , S. C. , I. D. , L. T. , K. A. W. , S. S. and S. U.: writing—reviewing and editing. All authors have read and agreed to the published version of the manuscript. FundingThis research received no external funding. Institutional Review Board StatementNot applicable. Informed Consent StatementNot applicable. Data Availability StatementData available in a publicly accessible repository that does not issues DOIs. Conflicts of InterestThe authors declare no conflict of interest. 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Proceedings 2024, 100, 22. https: //doi. org/10. 3390/proceedings2024100022 AMA Style Mishra DK, Yadav S, Chaudhari S, Dixit I, Tiwari L, Abdul Waheed K, Shukla S, Upadhyay S. Metabolic Strategies of Treg Cells in the Tumor Microenvironment: Implications for Immune Metabolism-Based Precision Medicine. Proceedings. 2024; 100 (1): 22. https: //doi. org/10. 3390/proceedings2024100022 Chicago/Turabian Style Mishra, Devendra Kumar, Sandeep Yadav, Sumit Chaudhari, Ila Dixit, Lavkush Tiwari, Khalid Abdul Waheed, Shubham Shukla, and Savita Upadhyay. 2024. "Metabolic Strategies of Treg Cells in the Tumor Microenvironment: Implications for Immune Metabolism-Based Precision Medicine" Proceedings 100, no. 1: 22. https: //doi. org/10. 3390/proceedings2024100022 Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view.