A 2-hour urine output assessment is sufficient to evaluate diuretic response in acute heart failure, with 81.25% achieving satisfactory output.
Does a 2-hour assessment of urine output reliably evaluate diuretic response compared to a 6-hour assessment after IV furosemide in acute heart failure?
A 2-hour assessment of urine output is comparable to a 6-hour assessment, suggesting it is sufficient to evaluate diuretic response and guide dose adjustments in acute heart failure.
Absolute Event Rate: 0% vs 0%
Abstract Objectives This study compared urine output at 2 and 6 h post-furosemide and explored factors influencing diuretic efficacy in acute heart failure (AHF). Methods A prospective study (June–August 2023) included AHF patients (≥18 years) with NT-proBNP ≥300 pg/mL. Urinary spot sodium and urine output were measured at baseline, 2, and 6 h after 40 mg IV furosemide. Results Among 32 patients, 26 (81.25 %) had satisfactory urine output, and 30 (93.75 %) met the target urinary sodium concentration at 2 h. No significant difference in mean urine output was found between the 2 and 6 h intervals (267 ± 189 mL vs. 298 ± 149 mL, p=0.099). Urine output correlated strongly with urinary sodium concentration (p < 0.001, R 2 =0.683). Serum creatinine was a significant predictor of urine output (p=0.007). Conclusions The comparable urine output at 2 and 6 h suggests that a 2 h assessment may be sufficient to evaluate diuretic response and guide dose adjustments in AHF.
Alsagaff et al. (Thu,) reported a other. A 2-hour urine output assessment is sufficient to evaluate diuretic response in acute heart failure, with 81.25% achieving satisfactory output.
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