March 3, 2011Open Access
Diuretic Strategies in Patients with Acute Decompensated Heart Failure
Structured PICO
Does diuretic therapy administered by bolus or high dose improve symptoms or renal function in patients with acute decompensated heart failure?
P
Population
Patients with acute decompensated heart failure
I
Intervention
Diuretic therapy administered by bolus or at a high dose
C
Comparator
Diuretic therapy administered by continuous infusion or at a low dose
O
Outcome
Patients' global assessment of symptoms or change in renal functionpatient reported
In patients with acute decompensated heart failure, the strategy of diuretic administration (bolus vs. continuous infusion, high vs. low dose) does not significantly affect symptom relief or short-term renal function.
Abstract
Among patients with acute decompensated heart failure, there were no significant differences in patients' global assessment of symptoms or in the change in renal function when diuretic therapy was administered by bolus as compared with continuous infusion or at a high dose as compared with a low dose. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, NCT00577135.).
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Authors
G. Michael Felker
University of Vermont
K
Kerry L. Lee
Northwestern University
D
David A. Bull
Cardiac Surgery
Journals
New England Journal of Medicine
Actions
Institutions
Brigham and Women's Hospital
Massachusetts General Hospital
Duke University
References and Citations
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