Why the study?
Does diuretic therapy administered by bolus or high dose improve symptoms or renal function in patients with acute decompensated heart failure?
Does diuretic therapy administered by bolus or high dose improve symptoms or renal function in patients with acute decompensated heart failure?
In patients with acute decompensated heart failure, the strategy of diuretic administration (bolus vs. continuous infusion, high vs. low dose) does not significantly affect symptom relief or short-term renal function.
Diuretic strategy does not impact symptoms or renal function in acute decompensated HF; confirms equivalence of bolus versus infusion and high versus low dosing.
Among patients with acute decompensated heart failure, there were no significant differences in patients' global assessment of symptoms or in the change in renal function when diuretic therapy was administered by bolus as compared with continuous infusion or at a high dose as compared with a low dose. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov number, NCT00577135.).
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Felker et al. (2011) studied this question.
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